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KMID : 0043319980210050570
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.570 ~ p.575
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Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Homosulfamine Complex
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Ha Neung-Jin
Jung Yun-Jin
Lee Jeoung-Soo
Kim Yong-Taeg
Kim Young-Mi
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Abstract
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To develop a cotton derivatives with prolonged antimicrobial activities, homosulfamine (Hs) was coupled to cotton xanthate (CX) via chelate bond in the presence of Cu(II) ion by one- and two-bath processes. In one-bath process, CX was treated with Cu(II)-Hs solution. In two-bath process, CX was treated with Cu(II) ion solution to produce CX-Cu(II) complex, which was isolated and treated in turn with Hs solution. Effects of concentration, Cu(II)/Hs ratio, and pH on the binding of Hs were investigated at . In one-bath process, binding of hs took place readily with optimum pH around 5-6. the amount of binding increased to give a maximum within 5 min and decreased slowly to establish an equilibrium withhin an hour. In two-bath process, binding of Hs was much lower than that of one-bath process. Release of Hs from CX-Cu(II)-Hs was investigated by batch and flow method. antimicrobial activiteis of CX-Cu(II)-Hs was investigated by batch and flow method. Antimicrobial activities of CX-Cu(II)-Hs were tested against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli and it showed prolonged activity compared to that of free Hs.
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KEYWORD
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Cotton xanthate-Cu(ll)-honosulfamine complex, Cotton derivatives, Antimicrobial activity
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